Leading Edge Technology for Particle Size and Shape

Ankersmid Ltd is a company based in Israel with leading-edge technology for Particle Size and Shape determination.  The revolutionary technique based on the Time of Transition Theory combined with Dynamic Shape Analysis using the high speed CCD Camera provide accurate information on Particle Size and Shape.

Ankersmid offers systems for Particle analysis, particle size and particle shape monitoring with laser, supplying the latest In-Lab particle analysers and taylored solutions for on-line and add-line particle size and shape analysis.

List of Technologies Available :

Particle Size Analyzers Product Overview

Particle size analyzers are used to determine the size of particles and their state of distribution and they are used for the production control of powders in such fields as pharmaceuticals, cement, ceramics, chemistry and foodstuffs.

Ankersmid uses a revolutionary technique to determine the size of the particles based on the Time of Transition Theory.

Vacuum system creates uniform dispersal of dry powder samples on to microscope slides, giving highly reproducible and representative slide preparation suitable for automatic image analysis software.

The preparation of dry powders for microscopic analysis is a challenging task. In absence of a standardised procedure, microscopists tend to develop their own, product-specific methods. The challenges in dry powder slide preparation are to obtain a uniformly dispersed mono-layer of particles and to avoid particle clusters, while maintaining the structure of fragile primary particles.

With the Ankersmid PD-10, the company says a standard method for uniform dry powder dispersion on microscopic slides has become available.

Moreover, the tedious and time-consuming task of manually selecting and counting particles by staring through a microscope can now be automated with Ankersmid's Eyetech image analysis software.

A small quantity of powder is placed in a well at the top of the cylindrical reservoir of the powder disperser.  After the vacuum is applied with an abrupt trigger, the vacuum seal is momentarily opened.  The sample is instantaneously sucked into the vacuum reservoir. The abrupt suction creates turbulent flow with high Reynolds numbers and high shear forces, causing agglomerates to be broken, and the particles to be dispersed uniformly in the reservoir volume.

Gravitational sedimentation then occurs, simulating the process of isokinetic sampling. The vacuum in the reservoir minimises aerodynamic drag on the particles. Therefore, all particles settle down with the same linear velocity, independent of the particle size.  High shear forces and uniform deposition are created during sample introduction in the PD-10, thus eliminating problems of overlapping particles, agglomeration and clusters that occur with the usual manual preparation for microscope examination.

Slide preparation the PD-10 is highly reproducible, says the company; different users consistently achieve identical results.  Uniformly dispersed particles on a microscope slide result in a statistically representative sample for accurate measurement.  Easy access to all parts of the system enables cleaning in less than one minute to prevent cross contamination of sample.

A wide variety of dry samples can be prepared including fluffy powders, dense powders, and hazardous or toxic powders.

 Ankersmid's Eyetech image analysis software.

Microscopic analysis of the prepared slides can be performed using Ankersmid's Eyetech image analysis software.  With the Eyetech software, the particle size and shape of thousands of particles is automatically measured in a matter of minutes.  Measurement methods are set-up and performed using intuitive wizards, following incorporated standard operating procedures (SOP).  Eyetech image analysis software includes automatic procedures for contrast enhancement, image filters, morphology operations, and grouping which are readily incorporated in the SOP.

Procedures for automatic saving of images, movies and re-processing of previously stored images or measurements are available.  Calibration procedures for multiple lenses are implemented.  Access to system configuration, calibration, measurement set-up is managed through a multiple user level database ensuring 21 CFR Part 11 compliance. The results are stored in the database and custom statistical reports for all size and shape parameters can be generated.

Over 40 size and shape related parameters are included, such as equivalent diameter, min/max diameter, ferret diameters, aspect ratio, shape factor, specific length/width.  Results are displayed in both graphical and tabular format; statistical means for particle size distributions are calculated.

Eyetech Microscopy

Eyetech Microscopy is an additional tool for microscopy, containing everything required to perform fast, accurate and reproducible microscopic inspection of dry powders. The Eyetech microscopy packages includes the PD-10 dry powder disperser, ACU, Ankersmid control unit, CCD camera, Eyetech image analysis software (21 CFR Part 11 Compliant), Microsoft Windows XP, and Microsoft Office 2003

• Quartz & optical Glass cuvette cells, for optical instruments use.

• Powder disperser, for uniform preparation of microscope slides.

• Image analysis software, for microscopic shape analysis applications.

• Particle size shape & concentration measurement, for QC-QA R&D general applications.

• Elemental chemical detectors & analyzers, for many chemical detection applications.

• Sorption humidity analyzers generators, for sorption and humidity measurements.

• High quality Atomic Absorption Spectrometers, and Atomic Fluorescence Spectrometers

• Patented Gravimetric suspension balance, for weighing under extreme physical conditions